Robosante

The exact mechanism of action of ibuprofen is not fully understood, but it is thought to work by reversibly inhibiting the enzymes cyclooxygenase-1 and 2 (COX-1 and COX-2). This inhibition leads to a decrease in the production of prostaglandins, which are inflammatory mediators. Ibuprofen also decreases the production of thromboxane, which is a blood clotting factor

Indigestion, nausea, vomiting, abdominal pain, constipation, headache, dizziness, lightheadedness, insomnia, drowsiness, rash, increased AST or ALT, fluid retention, tinnitus, ecchymosis, sensitivity to light, delayed ovulation, urticaria, itching, conjunctivitis. , blurred vision, headache, fever, seizures, drop in blood pressure, metallic taste in the mouth, nasal congestion, decrease in hemoglobin,

If you are taking the following medicines, consult your doctor or pharmacist.

Aspirin (ASA), acetaminophen, anticoagulants (blood thinners such as warfarin), digoxin, oral antidiabetic drugs and insulin, diuretics (such as hydrochlorothiazide), methotrexate, lithium, protein-bound drugs such as probenecid, thyroxine, antibiotics , cyclosporine, phenytoin, corticosteroids or benzodiazepines, other NSAIDs or antihypertensives.

NSAIDs increase the risk of serious thrombotic cardiovascular events such as myocardial infarction and stroke, which can occur at the beginning or during the course of treatment. For this reason, their use is prohibited in suspected cardiac pain and before CABG surgery.
Due to the possibility of ulcers and bleeding and rupture of the gastrointestinal tract as a result of excessive use of NSAIDs, it should be used with more caution in the elderly and patients with a history of gastrointestinal bleeding or peptic ulcer. Gastrointestinal complications may occur at any time with or without warning symptoms. For this reason, it is necessary to give the necessary training to the patient and emphasize on taking it with food.
The patient should be taught to avoid taking several painkillers or painkillers at the same time in order to better control the symptoms.

History of allergy to ibuprofen, methocarbamol or similar drugs
Asthma associated with ASA or NSAID or aspirin triad (bronchial asthma, aspirin intolerance, rhinitis)
Before CABG surgery
CrCl <30
Advanced kidney and liver disorders
Pregnancy from the beginning of the 30th week
Cerebrovascular bleeding or other bleeding disorders
Active gastrointestinal ulcer or bleeding
breastfeeding
Systemic lupus erythematosus

Group C

It can be used in special conditions and under the special supervision of a doctor: animal studies have shown cases of side effects for the fetus, and human studies are not enough. The benefits of the drug against possible risks determine the use or non-use of this drug during pregnancy.